Properties
Description
H-1152 blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets Abl, AMPK, AuroraA, and CaMKII.
Molecular Formula
C16H21N3O2S
Targets
Abl: 7.77 μM; AMPK: 100 μM; AuroraA: 0.745 μM; CaMKII: 0.18 μM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
H-1152 is utilized to study its inhibitory effects on Rho-kinase in cellular contractility research.