Properties
Description
Hydroxyfasudil blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets PKA, ROCK1, and ROCK2.
Molecular Formula
C14H17N3O3S
Targets
PKA: 37 μM; ROCK1: 0.73 μM; ROCK2: 0.72 μM
Identity
Confirmed by NMR/HPLC/MS.
Applications
Hydroxyfasudil can be used to study inhibition of Rho kinase for therapeutic applications in cardiovascular diseases.