Properties
Description
RKI-1447, soluble in DMSO and insoluble in ethanol and water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 and ROCK2.
Molecular Formula
C16H14N4O2S
Targets
ROCK1: 14.5 nM; ROCK2: 6.2 nM
Solubility
DMSO: 62 mg/mL (189.97 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
RKI-1447 is utilized to investigate its inhibitory effects on ROCK1 and ROCK2 in the study of cell migration and invasion.