ROCK inhibitor RKI-1447, Purity ≥98%

Synonym: 1342278-01-6; RKI1447; RKI 1447. ROCK inhibitor XIII; ROCK inhibitor

CAS Number: 1342278-01-6
Compound CID: 60138149

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RKI-1447, soluble in DMSO and insoluble in ethanol and water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 and ROCK2.

Molecular Weight

326.37

Molecular Formula

C₁₆H₁₄N₄O₂S

Targets

ROCK1: 14.5 nM; ROCK2: 6.2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 62 mg/mL (189.97 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

RKI-1447 is utilized to investigate its inhibitory effects on ROCK1 and ROCK2 in the study of cell migration and invasion.

Storage

Store at -20ºC.