Properties
Description
ROCK inhibitor, soluble in DMSO and ethanol and insoluble in water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets FLT3, ROCK-1, ROCK-2, and TRK.
Molecular Formula
C18H13ClF2N6O
Targets
FLT3: 303 nM; ROCK-1: 0.6 nM; ROCK-2: 1.1 nM; TRK: 252 nM
Solubility
DMSO: 77 mg/mL (191.16 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.96 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ROCK inhibitor can be employed to research its effects on inhibiting Rho-associated protein kinases in various physiological and pathological processes.
