Properties
Description
SR 3677 dihydrochloride blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK-I and ROCK-II.
Molecular Formula
C22H24N4O4.2HCl
Targets
ROCK-I: 56 nM; ROCK-II: 3 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
SR 3677 dihydrochloride is employed to study its selective inhibition of ROCK2 in cell signaling.