ROCK inhibitor Y-27632 2HCl, Purity ≥98%

Synonym: y-27632; 146986-50-7; Y27632; Y 27632; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide; ROCK inhibitor

CAS Number: 146986-50-7, 129830-38-2
Compound CID: 448042

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Y-27632 2HCl, soluble in warmed DMSO and water and insoluble in ethanol, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 (p160ROCK) and ROCK2.

Molecular Weight

320.3

Molecular Formula

C₁₄H₂₁N₃O.2HCl

Targets

ROCK1 (p160ROCK): 140 nM (Ki); ROCK2: 300 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 61 mg/mL (190.46 mM); Water: 13 mg/mL (40.59 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Y-27632 2HCl can be used to investigate its role in inhibiting Rho kinase and its applications in stem cell research and cancer therapy.

Storage

Store at -20ºC.