ROCK inhibitor Y-33075 dihydrochloride, Purity ≥98%

Synonym: 173897-44-4; Y-33075 dihydrochloride; Y-39983 dihydrochloride; (R)-4-(1-Aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide dihydrochloride; Y-33075 (dihydrochloride); 4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide; ROCK inhibitor

CAS Number: 173897-44-4
Compound CID: 20601328

Product Size

250 mg; 500 mg; 1000 mg; 2000 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Y-33075 dihydrochloride, soluble in DMSO, water and ethanol, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets CaMKII, PKC, and ROCK.

Molecular Weight

353.25

Molecular Formula

C₁₆H₁₈Cl₂N₄O

Targets

CaMKII: 810 nM; PKC: 420 nM; ROCK: 3.6 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 60 mg/mL (169.85 mM); Water: 60 mg/mL (169.85 mM); Ethanol: 2 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Y-33075 dihydrochloride can be used for studying the effects of Rho-associated protein kinase (ROCK) inhibition in a variety of cellular processes, such as smooth muscle contraction and cell migration.

Storage

Store at -20ºC.