Properties
Description
Y-33075 dihydrochloride, soluble in DMSO, water and ethanol, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets CaMKII, PKC, and ROCK.
Molecular Formula
C16H18Cl2N4O
Targets
CaMKII: 810 nM; PKC: 420 nM; ROCK: 3.6 nM
Solubility
DMSO: 60 mg/mL (169.85 mM); Water: 60 mg/mL (169.85 mM); Ethanol: 2 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Y-33075 dihydrochloride can be used for studying the effects of Rho-associated protein kinase (ROCK) inhibition in a variety of cellular processes, such as smooth muscle contraction and cell migration.