Properties
Description
Y-33075 blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets CaMKII, PKC, and ROCK.
Molecular Formula
C16H16N4O
Targets
CaMKII: 810 nM; PKC: 420 nM; ROCK: 3.6 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Y-33075 can be used to investigate the inhibition of Rho-associated protein kinase (ROCK), which plays a role in cytoskeleton organization and cell motility.