Properties
Description
Rotundine, soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A, D1 receptor, D2 receptor, and D3 receptor.
Molecular Formula
C21H25NO4
Targets
5-HT1A: 347 nM; D1 receptor: 166 nM; D2 receptor: 1.47 μM; D3 receptor: 3.25 μM
Solubility
DMSO: 8 mg/mL (22.5 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Rotundine can be used as a calcium channel blocker.
Storage
Store at -20°C, and keep desiccated.