Properties
Description
RS 127445 HCl inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT5 receptor, 5-HT6 receptor, and sPLA2.
Molecular Formula
C17H17ClFN3
Targets
5-HT2A receptor: 6.3 (pKi); 5-HT2B receptor: 9.5 (pKi); 5-HT2C receptor: 6.4 (pKi); 5-HT3 receptor: <6 (pKi); 5-HT5 receptor: <6 (pKi); 5-HT6 receptor: <6 (pKi); sPLA2: 5.5 (pKi)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
RS 127445 HCl can be used for its ability to reduce pulmonary vascular resistance and improve blood flow in the lungs.
Storage
Store at -20°C, and keep desiccated.
