Properties
Description
LJH685, soluble in DMSO and ethanol and insoluble in water, attenuates the activity of kinases involved in cell growth, survival, and proliferation, which can be utilized to inhibit tumor progression. It targets RSK1, RSK2, and RSK3.
Molecular Formula
C22H21F2N3O
Targets
RSK1: 6 nM; RSK2: 5 nM; RSK3: 4 nM
Solubility
DMSO: 66 mg/mL (173.03 mM); Water: Insoluble; Ethanol: 17 mg/mL (44.57 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
LJH685 can be used to investigate its selective inhibition of AKT signaling pathways in cancer research.
