Ruboxistaurin hydrochloride

Synonym: 169939-93-9; LY-333531

CAS Number: 169939-93-9
PubChem CID: 9870785

Product Size

2 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Ruboxistaurin (LY333531 HCl), soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβI, PKCβII, PKCδ, PKCε, PKCη, and PKCγ.

Molecular Weight

505.01

Molecular Formula

C₂₈H₂₈N₄O₃·HCl

Targets

PKCα: 360 nM; PKCβI: 4.7 nM; PKCβII: 5.9 nM; PKCδ: 250 nM; PKCε: 600 nM; PKCη: 52 nM; PKCγ: 300 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 49 mg/mL (97.02 mM); Water: insoluble; Ethanol: insoluble

Applications

Ruboxistaurin (LY333531 HCl) can be used for its efficacy in diabetic neuropathy, another complication of diabetes involving nerve damage.