Properties
Description
Ruboxistaurin (LY333531 HCl), soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβI, PKCβII, PKCδ, PKCε, PKCη, and PKCγ.
Molecular Formula
C28H28N4O3·HCl
Targets
PKCα: 360 nM; PKCβI: 4.7 nM; PKCβII: 5.9 nM; PKCδ: 250 nM; PKCε: 600 nM; PKCη: 52 nM; PKCγ: 300 nM
Solubility
DMSO: 49 mg/mL (97.02 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ruboxistaurin (LY333531 HCl) can be used for its efficacy in diabetic neuropathy, another complication of diabetes involving nerve damage.
Storage
Store at -20℃, and keep desiccated.
