Properties
Description
SB 271046 Hydrochloride, soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT1F receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT4 receptor, 5-HT6 receptor, 5-HT7 receptor, and human 5-HT2C receptor.
Molecular Formula
C20H23Cl2N3O3S2
Targets
5-HT1A receptor: 6.35 (pKi); 5-HT1B receptor: 6.05 (pKi); 5-HT1D receptor: 6.55 (pKi); 5-HT1E receptor: <4.99 (pKi); 5-HT1F receptor: 5.95 (pKi); 5-HT2A receptor: 5.62 (pKi); 5-HT2B receptor: 5.41 (pKi); 5-HT4 receptor: 5.27 (pKi); 5-HT6 receptor: 8.92-9.02 (pKi); 5-HT7 receptor: 5.39 (pKi); Human 5-HT2C receptor: 5.73 (pKi)
Solubility
DMSO: 38 mg/mL (77.8 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
SB 271046 Hydrochloride can be used to research and develop therapeutic strategies for certain diseases that involve excessive activation of GPCR-G protein signaling pathways.
Storage
Store at -20°C, and keep desiccated.
