SIK inhibitor ARN-3236, Purity ≥98%

Synonym: 1613710-01-2; ARN-3236; 3-(2,4-dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine; CHEMBL4539742; 3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine; 3-(2,4-Dimethoxyphenyl)-4-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine; SIK inhibitor

MDL: MFCD31813721
CAS Number: 1613710-01-2
Compound CID: 74766530

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ARN-3236, soluble in DMSO and ethanol and insoluble in water, is a potential salt-inducible kinase (SIK) inhibitor. It targets SIK1, SIK2, and SIK3.

Molecular Weight

336.4

Molecular Formula

C₁₉H₁₆N₂O₂S

Targets

SIK1: 21.63 nM; SIK2: <1 nM; SIK3: 6.63 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 62 mg/mL (184.3 mM); Water: Insoluble; Ethanol: 2 mg/mL (5.94 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

ARN-3236 can be used to investigate its role as an inhibitor of p300/CBP, relevant in cancer and epigenetic regulation.

Storage

Store at -20ºC.