Properties
Description
AK-7, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT2.
Molecular Formula
C19H21BrN2O3S
Solubility
DMSO: 77 mg/mL (176.06 mM); Water: Insoluble; Ethanol: 3 mg/mL (6.85 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AK-7 is applied to study the role of SIRT2 in Huntington's disease models by inhibiting its activity.
