Sirtuins inhibitor AK-7, Purity ≥98%

Synonym: 420831-40-9; AK7; Sirtuins inhibitor

CAS Number: 420831-40-9
Compound CID: 1328033

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AK-7, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT2.

Molecular Weight

437.35

Molecular Formula

C₁₉H₂₁BrN₂O₃S

Targets

SIRT2: 15.5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (176.06 mM); Water: Insoluble; Ethanol: 3 mg/mL (6.85 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AK-7 is applied to study the role of SIRT2 in Huntington's disease models by inhibiting its activity.