Properties
Description
Cambinol, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT1 and SIRT2.
Molecular Formula
C21H16N2O2S
Targets
SIRT1: 56 μM; SIRT2: 59 μM
Solubility
DMSO: 19 mg/mL (52.71 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Cambinol is used to examine the role of SIRT1 and SIRT2 in cancer and aging by inhibiting these enzymes.
