Sirtuins inhibitor Inauhzin, Purity ≥98%

Synonym: 309271-94-1; Inauhzin; 2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one; CHEMBL4787472; 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin); Sirtuins inhibitor

CAS Number: 309271-94-1
Compound CID: 5494506

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Inauhzin, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance.

Molecular Weight

469.58

Molecular Formula

C₂₅H₁₉N₅OS₂

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 82 mg/mL (174.62 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Inauhzin is used to investigate p53 regulation by inhibiting SIRT1 and modulating p53 acetylation.