Sirtuins inhibitor SirReal2, Purity ≥98%

Synonym: 709002-46-0; SirReal2; SirReal 2; 2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide; 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide; Sirtuins inhibitor

CAS Number: 709002-46-0
Compound CID: 1096292

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SirReal2, soluble in warmed DMSO and insoluble in water and ethanol, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT2.

Molecular Weight

420.55

Molecular Formula

C₂₂H₂₀N₄OS₂

Targets

SIRT2: 140 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 71 mg/mL (168.82 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

SirReal2 is employed to investigate selective SIRT2 inhibition and its potential therapeutic applications.