Sirtuins inhibitor Sirtinol, Purity ≥98%

Synonym: 410536-97-9; Sir two inhibitor naphthol; Sirtuins inhibitor

CAS Number: 410536-97-9
Compound CID: 2827646

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Sirtinol, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets hSIRT1, hSIRT2, and ySir2.

Molecular Weight

394.47

Molecular Formula

C₂₆H₂₂N₂O₂

Targets

hSIRT1: 131 μM; hSIRT2: 57.7 μM; ySir2: 48 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 20 mg/mL (50.7 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Sirtinol is applied to study the inhibition of SIRT1 and SIRT2 and their role in cellular aging and cancer.