Properties
Description
SRT 1460, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT1.
Molecular Formula
C26H29N5O4S
Targets
SIRT1: 2.9 μM (EC1.5)
Solubility
DMSO: 20 mg/mL (39.4 mM); Water: Insoluble; Ethanol: 1 mg/mL (1.97 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
SRT 1460 is a SIRT1 activator used to explore its role in metabolism and longevity.