Sirtuins inhibitor Thiomyristoyl, Purity ≥98%

Synonym: 1429749-41-6; Thiomyristoyl; CHEMBL4129995; Benzyl (S)-(1-oxo-1-(phenylamino)-6-tetradecanethioamidohexan-2-yl)carbamate; Benzyl N-[(2S)-1-anilino-1-oxo-6-(tetradecanethioylamino)hexan-2-yl]carbamate; Sirtuins inhibitor

CAS Number: 1429749-41-6
Compound CID: 126843233

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Thiomyristoyl, soluble in DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT1 and SIRT2.

Molecular Weight

581.86

Molecular Formula

C₃₄H₅₁N₃O₃S

Targets

SIRT1: 98 μM; SIRT2: 28 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (154.67 mM); Water: Insoluble; Warmed ethanol: 90 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Thiomyristoyl is investigated for its covalent inhibition of deacetylases, affecting protein acetylation.

Storage

Store at -20ºC.