Sirtuins inhibitor Thiomyristoyl, Purity ≥98%

Synonym: 1429749-41-6; Thiomyristoyl; CHEMBL4129995; Benzyl (S)-(1-oxo-1-(phenylamino)-6-tetradecanethioamidohexan-2-yl)carbamate; Benzyl N-[(2S)-1-anilino-1-oxo-6-(tetradecanethioylamino)hexan-2-yl]carbamate; Sirtuins inhibitor

CAS Number: 1429749-41-6
Compound CID: 126843233

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Thiomyristoyl, soluble in DMSO and warmed ethanol and insoluble in water, is a compound that blocks the activity of sirtuins, a family of NAD+-dependent deacetylases involved in the regulation of aging, metabolism, and stress resistance. It targets SIRT1 and SIRT2.

Molecular Weight

581.86

Molecular Formula

C₃₄H₅₁N₃O₃S

Targets

SIRT1: 98 μM; SIRT2: 28 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (154.67 mM); Water: Insoluble; Warmed ethanol: 90 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Thiomyristoyl is investigated for its covalent inhibition of deacetylases, affecting protein acetylation.