Properties
Description
Sitaxsentan sodium (TBC-11251) inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets ET-A, and ET-A.
Molecular Formula
C18H14ClN2NaO6S2
Targets
ET-A: 1.4 nM; ET-A: 0.43 nM (Ki)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Sitaxsentan sodium (TBC-11251) can be used to block the binding of endothelin to ETA receptors, thus inhibiting the vasoconstrictive and proliferative effects of endothelin.
Storage
Store at -20°C, and keep desiccated.
