CD BioGlyco provides an integrated solution of Antibody Glycoengineering. Our advanced Glycoengineering Platform and high-quality site-specific antibody conjugation services will fully meet your needs. We have the confidence to be your essential research assistant in the field of glycobiology.
Antibody-drug conjugates are a promising class of tumor-targeted therapeutic drugs. The cell selectivity of monoclonal antibodies can selectively destroy malignant cells while sparing healthy tissue. The key to the construction of this conjugate is the covalent linker between the two components. The combination of macromolecular biology and small-molecule chemistry is the key to the success of antibody-drug conjugates.
Fig.1 Antibody-drug conjugates structures showing different sites of attachment to mAb of the drug with the linker. MMAE = monomethyl auristatin E, an extremely potent synthetic antineoplastic agent. (Dong, et al., 2018)
To improve conventional conjugation methods to generate these heterogeneous products, various site-specific methods have been developed. These methods conjugate functional small molecules to specific sites in antibody molecules, including cysteine, glutamine, unnatural amino acids, short peptide tags, and glycans. The resulting antibody-drug conjugates showed high homogeneity and potent antitumor activity both in vitro and in vivo.
Chemically defined antibody conjugates can be synthesized in commercially relevant yields and generate antibody-drug conjugates with improved properties relative to heteroconjugates formed by non-specific chemical modification. Site-specific antibody-drug conjugates produced by enzymatic modification also show improved stability and pharmacokinetics.
Fig.2 Strategies to functionalise cysteine-engineered antibodies to generate homogeneous antibody-drug conjugates. (Walsh, et al., 2021)
CD BioGlyco provides advanced technologies for the site-specific conjugation of IgG with Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 647, biotin, DFO, or azide. The technologies sre implemented using Fc glycan remodeling and a click chemistry approach.
In addition, we provide you with custom antibody conjugate services if our existing site-specific antibody conjugation services do not meet your specific needs. Our custom conjugate services are efficient and quality-assured.
With extensive experience, rich industry knowledge, and an advanced Glycoengineering Platform, CD BioGlyco is committed to making a difference in your program of site-specific antibody conjugation to develop a favorable candidate. Our world-class scientists and technicians will cooperate closely with our clients to accelerate the project. For more detailed information and quote, please feel free to contact us for deep communication.
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