The Partner You Need for Sodium Starch Glycolate (SSG) Analysis

CD BioGlyco provides comprehensive Pharmaceutical and Biological Analysis solutions including Pharmaceutical Analysis, Biological Evaluation, and Pharmaceutical Excipient Analysis services. SSG is the sodium salt of starch carboxymethyl ether produced by starch acting with chloroacetic acid under alkaline conditions. It is necessary to analyze SSG for source, particle size, amount of sodium chloride (reaction by-product), viscosity, degree of substitution, and cross-linking type, as these are closely related to the functionality of SSG.

• Identification
  • Microscopy: Our researchers place liquid paraffin-mounted SSGs under the microscope. The characteristics of starch are varied greatly from one source to another. Potato starch is characterized as a single granule, ovoid, round, or pear-shaped, with diameters ranging from 30 μm to 100 μm. Corn starch is characterized as a single granule, polygonal or round-like, with diameters ranging from 5 μm to 30 μm.
  • Chromogenic reaction: Our researchers identify SSG by adding an iodized test solution to an aqueous solution of SSG and observing for an immediate blue color.
  • Flame reaction: Our researchers determine SSG by burning a platinum wire with SSG in a colorless flame and observing the color of the flame.
• Basic test
  • Our team provides some simple analyses including swelling volume analysis, loss on drying analysis, microbial limit test, and pH analysis.
• Content test
  • Sodium chloride: We offer accurate sodium chloride quantification services by silver nitrate titration.
  • Sodium glycolate: After dissolution, precipitation, filtration, and dilution of sodium glycolate, we measure its absorbance at 540 nm using UV-Vis spectrophotometry.
  • Chloroacetic acid: We offer chloroacetic acid determination using anion exchange chromatography. Our researchers calculate the peak area of the standard and the test SSG according to the external standard method.
• Structure and particle size distribution test
  • Particle size and size distribution: We use light scattering to determine the particle size and size distribution of SSG. By measuring the energy distribution of the scattered light (scattering angle), our researchers calculate the particle size distribution of the particles.
  • Structural characterization: we use Fourier transform infrared (FTIR), scanning electron microscopy (SEM) analysis, differential scanning calorimetry (DSC) analysis, magnetic resonance imaging (MRI), and X-ray diffraction (XRD) to analyze the structure of SSG.

Applications of SSG Analysis

• SSG analysis be used to evaluate the quality of super disintegrant tablets or capsules.
• SSG analysis further expands the use of SSG in disintegrants, suspending agents, and gelling agents.
• SSG analysis plays an important role in formulation development and in assessing the impact of excipient variability on final product quality.

Advantages of Us

• Our talented team has many years of experience in pharmaceutical excipient analysis to ensure high-quality and reliable analysis.
• Our researchers offer a very comprehensive range of analyses including not only rapid identification and basic analysis but also quantitative analysis and complex structural characterization.
• We provide quantitative services that are time-consuming, highly accurate and reproducible.

CD BioGlyco provides professional pharmaceutical and biological analysis to clients worldwide. We provide the most suitable analytical solutions according to the client's needs and pharmaceutical excipient properties. For any further information, do not hesitate to contact us.