Delve Deep with Precision, Trust Our Sodium Stibogluconate (SSG) Analysis

SSG, a pentavalent antimony derivative with molecular formula C₁₂H₃₇Na₃O₂₇Sb₂ produced by the reaction of antimony acid and gluconic acid, is often used for its effect against leishmaniasis. CD BioGlyco provides high-quality SSG analysis services with deep biological knowledge and cutting-edge Pharmaceutical and Biological Analysis technology. The services we provide include but are not limited to, the following.

• Physical properties
  SSG is a white to light yellow amorphous powder, easily soluble in hot water and insoluble in ethanol or ether.
• Identification
  The sample to be analyzed is well dissolved in water, followed by the addition of dilute hydrochloric acid to it to adjust the pH. After that, potassium iodide solution is added to it and the color change of the solution is observed. If the solution appears brown, then continue to add starch solution to it. After adding starch solution, if the solution changes from brown color to blue color, then this sample is proved to be SSG.
• Chloride assay in SSG
  We dissolve the SSG well in water add tartaric acid and dilute nitric acid to it until the solution is clarified. Finally, we compare this solution with the standard sodium chloride solution against a black background. If the two solutions are in the same state, it means that the SSG contains chloride.
• Sulfate assay in SSG
  A sample of SSG is dissolved in water and hydrochloric acid, after which an appropriate amount of barium chloride solution is added to it and compared with a standard potassium sulfate solution against a black background. If the two solutions are in the same state, the sample contains sulfate.
• Lead salt assay in SSG
  Tartaric acid, sodium hydroxide, potassium cyanide, and sodium sulfide are added to a sample of sodium stibogluconate, and the color of the solution is observed and compared to a standard lead solution at CD BioGlyco.
• Loss on drying
  A sample of SSG is dried under reduced pressure at elevated temperature to a constant weight and weighed before and after drying. The loss of weight of the standardized SSG should not exceed 15.0%.
• Toxicological examination
  We dissolve by using lukewarm water, followed by letting it cool to room temperature. Finally, it is injected into mice from the tail vein. The toxicity of SSG is determined by the number of deaths in the mice.
• Content determination
  After accurately weighing SSG, we add water, hydrochloric acid, potassium iodide solution, and starch indicator solution to it in turn. Next, we titrate the solution with SSG. After the blue color of the solution disappears, we calculate the amount of SSG based on the amount of sodium thiosulfate used.

Fig.1 SSG analysis services. (CD BioGlyco)

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Advantages

• We possess the ability to analyze SSG in different types of samples.
• We offer custom pharmaceutical analysis solutions based on our client's research.
• We have a state-of-the-art Pharmaceutical Analysis technology platform and provide real-time feedback to our clients on the progress of their pharmaceutical analysis.

CD BioGlyco has many successes in pharmaceutical analysis. Our comprehensive services and robust data analysis have won us many accolades internationally. If you are interested in our services, please contact us for more details.