A well-established workflow for the characterization of spatial organization of glycans has been one of the growing demands. CD BioGlyco has various kinds of precise detecting instruments and proficient operators to provide spatial organization analysis of glycans. We have the confidence to provide customers with scientific services in glycan-related research.
A large number of proteins in eukaryotes are glycosylated and they play a variety of roles in physiological functions like molecular recognition. Therefore, glycosylation analysis is one of the indispensable approaches for developing antibody drugs and discovering biomarkers. Nowadays, various detection methods are emerging, among which LC-MS can detect and clarify the low abundance metabolites in the research of natural products. However, mass spectrometry (MS) can not provide information about the spatial and temporal distribution of metabolites in biological samples.
Imaging mass spectrometry (IMS) complements the traditional metabolomics and chemical analysis by combining qualitative and quantitative molecular information with spatial and temporal information. Moreover, MALDI-imaging mass spectrometry (MALDI-IMS) is a powerful technology, which can be used to study the spatial distribution of thousands of molecules in the whole tissue section through an experiment. MALDI-IMS has been used in many substances research, including metabolites, drugs, lipids, peptides, and proteins. However, its application in glycans is rarely reported.
Fig.1 Process of preparation of tissue slices for MALDI-IMS. (Feldman, 2013)
It has always been a difficult problem to accurately analyze the spatial organization of polysaccharides. In recent years, CD BioGlyco focuses on developing a variety of effective methods to analyze the structure of glycans to explore the structure and biological function of glycans, The services we provide include but are not limited to:
As a leading biotechnology company in the field of glycobiology, CD BioGlyco has professional platforms and project teams to provide personalized and customized solutions. We have long served enterprises and scientific research institutes. please contact us for scientific assistance, and we will gladly help you to bring your project to success.
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