Src inhibitor Dasatinib hydrochloride, Purity ≥98%

Synonym: 854001-07-3; Src inhibitor; BMS-354825 hydrochloride; Sprycel hydrochloride; BMS354825 hydrochloride; BMS 354825 hydrochloride

CAS Number: 854001-07-3
Compound CID: 11466607

Product Size

50 mg; 200 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dasatinib hydrochloride, soluble in DMSO, blocks the activity of Src kinases, which are involved in various cellular processes such as growth, differentiation, and survival, and have been implicated in the progression of several cancers and other diseases. It targets Bcr-Abl, c-Kit, FGFR1, Her1, Her2, lck, MEK, p38, PDGFRβ, Src, and yes.

Molecular Weight

524.47

Molecular Formula

C₂₂H₂₇Cl₂N₇O₂S

Targets

Bcr-Abl: 1.0 nM; c-Kit: 5.0 nM; FGFR1: 880 nM; Her1: 180 nM; Her2: 710 nM; lck: 0.4 nM; MEK: 1700 nM; p38: 100 nM; PDGFRβ: 28 nM; Src: 0.5 nM; yes: 0.5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (162.06 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Dasatinib hydrochloride, an Src and Bcr-Abl inhibitor, is extensively studied in various malignancies, including leukemia.