Stearoyl-CoA desaturase (SCD) inhibitor, MK-8245, Purity ≥98%

Synonym: 1030612-90-8; MK8245; 2-[5-[3-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid; 2H-Tetrazole-2-acetic acid, 5-(3-(4-(2-bromo-5-fluorophenoxy)-1-piperidinyl)-5-isoxazolyl)-; 2-[5-[3-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid; Stearoyl-CoA desaturase (SCD) inhibitor

MDL: MFCD20039622
CAS Number: 1030612-90-8
Compound CID: 24988881

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MK-8245, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting stearoyl-CoA desaturase (SCD). The molecular weight of the compound is 467.3, and its molecular formula is C₁₇H₁₆BrFN₆O₄. It targets the SCD1 (human), SCD1 (mouse) and SCD1 (rat).

Molecular Weight

467.3

Molecular Formula

C₁₇H₁₆BrFN₆O₄

Targets

SCD1 (human)

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 89 mg/mL (190.47 mM); Water: insoluble; Ethanol: insoluble; In vivo: 1% CMC + 0.5% Tween-80, 28 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

MK-8245 can be studied extensively for its potential therapeutic applications in the treatment of Alzheimer’s disease, aiming to reduce amyloid plaque formation.