Sucrose octaacetate, a commonly used pharmaceutical excipient, is a bitter substance frequently employed as a substitute for bitter active pharmaceuticals to enhance drug acceptance and improve properties such as drug stability and bioavailability. It continues to be utilized in fundamental physiological and pharmacological studies related to taste masking and taste mechanisms and serves as a bitter substitute in pediatric taste studies. CD BioGlyco has been at the forefront of providing clients with a comprehensive Pharmaceutical and Biological Analysis Service for many years. We offer a specialized Pharmaceutical Excipient Analysis Service, which focuses on the testing and evaluation of excipients used in drug formulations.
Technology: FT-IR and NMR
Journal: Chemical and Biochemical Engineering Quarterly
IF: 1.5
Published: 2017
Results: This article focuses on a green synthetic approach to esterify sucrose with acetic anhydride using ultrasound-assisted radiation to obtain sucrose octa-acetylsucrose. The article characterizes sucrose octa-acetylsucrose by FT-IR and NMR spectroscopy, confirms the occurrence of the acetylation reaction, and reveals the effect of hydrophobic substitution on the sucrose molecule. In addition, the article evaluates the foaming, foam stability, emulsification, and antimicrobial properties of sucrose octaacetate.
Fig.1 Synthesis of sucrose acetates using ultrasonic technology. (Petkova, et al., 2019)
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