CD BioGlyco is committed to providing professional sucrose stearate analysis services to our clients based on our long-standing experience in Pharmaceutical Excipient Analysis Service. Our goal is to meet the needs of our clients in quality control and product development, ensuring that their products meet the highest standards. Our sucrose stearate analysis services include but are not limited to the following.
Technology: Optical microscopy and laser diffractometer
Journal: Pharmaceutics
IF: 5.4
Published: 2011
Results: This article focuses on the application of semi-solid sucrose stearate emulsions as skin delivery systems. The article investigates different types of drugs that can be dermally delivered via semi-solid sucrose stearate emulsions, including water-soluble drugs, fat-soluble drugs, and amphoteric drugs. The results showed that semi-solid sucrose stearate emulsions have good stability and transdermal properties, and can effectively deliver drugs to the deeper layers of the skin. In addition, semi-solid sucrose stearate emulsions have low irritation and good biocompatibility for long-term use. In the article, semi-solid sucrose stearate was analyzed for its physical properties and its effect on the skin drug delivery system. Besides, the authors observed a complex network structure by optical microscopy, consisting of sucrose ester/water aggregates surrounding darker oil droplets. Rheological studies showed that semi-solid sucrose stearate has a pseudoplastic or shear-thinning rheological behavior, while the addition of a drug increases its viscosity. In terms of skin drug delivery system effects, the article evaluated the drug release properties of semi-solid sucrose stearate by in vitro diffusion cell and porcine ear stripping experiments. The results showed that the drug release rate of semi-solid sucrose stearate was influenced by its microstructure and viscosity.
Fig.1 Visual examination of nanoemulsions in their fresh and stored states using optical light microscopy. (Klang, et al., 2011)
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