Properties
Description
R935788, soluble in warmed DMSO and insoluble in water and ethanol, blocks the activity of spleen tyrosine kinase (Syk), a key protein involved in the signaling pathways of various immune cells and implicated in the pathogenesis of autoimmune diseases and certain cancers. It targets Syk.
Molecular Formula
C23H24FN6O9P.2Na
Solubility
Warmed DMSO: 5 mg/mL (8 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
R935788 inhibits tumor growth in the mouse model by blocking antigen-dependent B-cell receptor signaling.
