Synthesis

The invention of medical Oligonucleotides made medical treatment for genetic disorders revolutionary. On April 12, 2024, S. L. Lovelock's team from the University of Manchester published an article entitled "Modern approaches to therapeutic oligonucleotide manufacturing". The paper elaborates the way to optimize the efficiency of production, consistent products, large scale production to serve the market with […]

The growing demand for nucleic acid drugs and vaccines highlights the urgent need for improved technologies to produce long DNA and RNA sequences with Chemical Modifications. Unlike DNA, surprisingly little effort has been devoted to making therapeutic RNA Oligonucleotides longer than the short sequences (20-80 nt) used for small interfering RNA (siRNA) and microRNA (miRNA). In […]

The development of nucleic acid therapy requires efficient chemical reactions to connect oligonucleotides with functional chemical modules to improve their stability, promote cellular uptake and achieve specific targeting. In the currently used siRNA therapy, the 3' end of the oligonucleotide is mainly modified with triple-N-acetylgalactosamine (GalNAc)3. However, the implementation of this modification method requires cumbersome […]

As the basic components of RNA and DNA, purine nucleotides play an important role in cellular material metabolism and energy metabolism. For this reason, cells need an adequate supply of purine nucleotides to meet the needs of growth and proliferation. However, we still do not know how normal or malignant tumor tissues maintain nucleotide metabolic […]

Background With the application of nucleic acids in the treatment of diseases, human attention to nucleic acids in medicine is gradually increasing. In order to obtain a large amount of nucleic acids in a short time for use in the pharmaceutical field, the in vitro synthesis of nucleic acids is particularly important. The in vitro Synthesis of nucleic […]

Nucleotide Sugar is an activated form in the process of sugar conversion and synthesis, widely present in eukaryotes and prokaryotes. It is essential for the operation of physiological functions and even survival of organisms as a glycosyl donor in polysaccharide synthesis. Structurally, nucleotide sugars can be divided into nucleoside monophosphate (NMP)-sugar and nucleotide diphosphate (NDP)-sugar, […]

Glycosylation is a common tool in drug development. The introduction of sugar units can often change the water solubility, targeting, metabolic stability and other properties of the target molecule. However, the chemical method of introducing sugar units into the target molecule still faces many challenges. Most glycosylation reactions go through oxonium intermediates or their equivalents, […]

On June 17, 2024, the team of Dawen Niu from Sichuan University and Academician Yundong Wu from Peking University published a research paper titled "Catalytic Glycosylation for Minimally Protected Donors and Acceptors" in Nature. The study reports a Glycosylation platform that enables selective coupling between unprotected or minimally protected donor sugars and acceptor sugars to produce […]

Metabolic changes are a hallmark of cancer, supporting the rapid proliferation and survival of cancer under various stress conditions. Some metabolic activities have important detoxification functions, which prevent excessive accumulation of toxic metabolic intermediates. There is a "kitchen sink" model in cancer cells, where detoxification enzymes are needed only when the content of toxic metabolites in […]