Synthesis

The development of nucleic acid therapy requires efficient chemical reactions to connect oligonucleotides with functional chemical modules to improve their stability, promote cellular uptake and achieve specific targeting. In the currently used siRNA therapy, the 3' end of the oligonucleotide is mainly modified with triple-N-acetylgalactosamine (GalNAc)3. However, the implementation of this modification method requires cumbersome […]

As the basic components of RNA and DNA, purine nucleotides play an important role in cellular material metabolism and energy metabolism. For this reason, cells need an adequate supply of purine nucleotides to meet the needs of growth and proliferation. However, we still do not know how normal or malignant tumor tissues maintain nucleotide metabolic […]

Background With the application of nucleic acids in the treatment of diseases, human attention to nucleic acids in medicine is gradually increasing. In order to obtain a large amount of nucleic acids in a short time for use in the pharmaceutical field, the in vitro synthesis of nucleic acids is particularly important. The in vitro Synthesis of nucleic […]

Nucleotide Sugar is an activated form in the process of sugar conversion and synthesis, widely present in eukaryotes and prokaryotes. It is essential for the operation of physiological functions and even survival of organisms as a glycosyl donor in polysaccharide synthesis. Structurally, nucleotide sugars can be divided into nucleoside monophosphate (NMP)-sugar and nucleotide diphosphate (NDP)-sugar, […]

Glycosylation is a common tool in drug development. The introduction of sugar units can often change the water solubility, targeting, metabolic stability and other properties of the target molecule. However, the chemical method of introducing sugar units into the target molecule still faces many challenges. Most glycosylation reactions go through oxonium intermediates or their equivalents, […]

On June 17, 2024, the team of Dawen Niu from Sichuan University and Academician Yundong Wu from Peking University published a research paper titled "Catalytic Glycosylation for Minimally Protected Donors and Acceptors" in Nature. The study reports a Glycosylation platform that enables selective coupling between unprotected or minimally protected donor sugars and acceptor sugars to produce […]

Metabolic changes are a hallmark of cancer, supporting the rapid proliferation and survival of cancer under various stress conditions. Some metabolic activities have important detoxification functions, which prevent excessive accumulation of toxic metabolic intermediates. There is a "kitchen sink" model in cancer cells, where detoxification enzymes are needed only when the content of toxic metabolites in […]

Bergenin is the main bioactive component of the traditional Chinese medicine Ardisia japonica, which has multiple biological activities, including antitussive, anti-inflammatory, anti-diabetic and anti-cancer effects. Bergenin is mainly extracted from the rhizomes or stems of various plants, but its biosynthetic pathway remains unclear. The collaborative team of Jungui Dai from the Chinese Academy of Medical […]

On June 19, 2024, a collaborative team of Benjamin G. Davis from the University of Oxford and Ming Joo Koh from the National University of Singapore published a paper titled "Direct radical functionalization of native sugars" in Nature. They developed a biomimetic "cap and glycosylate" strategy that does not require metal catalysis and protecting groups, […]