Properties
Description
Tafamidis, soluble in DMSO and insoluble in water and ethanol, is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. The molecular weight of the compound is 308.12, and its molecular formula is C14H7Cl2NO3.
Molecular Formula
C14H7Cl2NO3
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 30 mg/mL (97.36 mM); Water: insoluble; Ethanol: insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Tafamidis can be studied extensively for its potential therapeutic applications in the treatment of transthyretin amyloidosis (ATTR), a condition characterized by the accumulation of misfolded proteins, leading to organ dysfunction, particularly affecting the heart and nervous system.
