Enzyme

August 24, 2024

Metabolic changes are a hallmark of cancer, supporting the rapid proliferation and survival of cancer under various stress conditions. Some metabolic activities have important detoxification functions, which prevent excessive accumulation of toxic metabolic intermediates. There is a "kitchen sink" model in cancer cells, where detoxification enzymes are needed only when the content of toxic metabolites in […]

July 26, 2024

Glycosylation is a key protein post-translational modification that affects protein folding, stability, activity and transport, and is an important quality attribute of protein drugs. A common glycoengineering method is to genetically modify the host cell's native glycosylation pathways, but this method is time-consuming and may interfere with normal cell growth and lead to a heterogeneous glycoprofile. […]