Properties
Description
BIBR 1532, soluble in DMSO and ethanol and insoluble in water, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting telomerase. It targets the telomerase (cell-free assay).
Molecular Formula
C21H17NO3
Targets
Telomerase (Cell-free assay): 100 nM
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 58 mg/mL (175.03 mM); Water: insoluble; Ethanol: 3 mg/mL (9.05 mM); In vivo: 5% DMSO + corn oil, 9 mg/mL
Applications
BIBR 1532 is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of cancers with defective DNA repair mechanisms, such as BRCA1/2-mutant cancers.
