TGF-β-Smad inhibitor GW788388, Purity ≥98%

Synonym: 452342-67-5; GW788388; 4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide; GW-788388; GW 788388; CHEMBL202887; N-(oxan-4-yl)-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}benzamide; TGF-β-Smad inhibitor

MDL: MFCD16038936
CAS Number: 452342-67-5
Compound CID: 10202642

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GW788388, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK5.

Molecular Weight

425.5

Molecular Formula

C₂₅H₂₃N₅O₂

Targets

ALK5: 18 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 15 mg/mL (35.25 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GW788388 can be used to investigate its inhibition of TGF-β receptor I kinase and its potential applications in treating fibrotic diseases.