TGF-β-Smad inhibitor LDN193189, Purity ≥98%

Synonym: 1062368-24-4; LDN193189; LDN-193189; 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline; LDN 193189; 4-[6-(4-Piperazin-1-Ylphenyl)pyrazolo[1,5-A]pyrimidin-3-Yl]quinoline; LDN193189 free base; TGF-β-Smad inhibitor

MDL: MFCD17169988
CAS Number: 1062368-24-4
Compound CID: 25195294

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LDN193189, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK2 (C2C12 cells) and ALK3 (C2C12 cells).

Molecular Weight

406.48

Molecular Formula

C₂₅H₂₂N₆

Targets

ALK2 (C2C12 cells): 5 nM; ALK3 (C2C12 cells): 30 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: Insoluble; Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

LDN193189 can be used to explore its inhibition of BMP type I receptors and its role in regulating cell differentiation and growth.