TGF-β-Smad inhibitor LY2157299, Purity ≥98%

Synonym: Galunisertib; 700874-72-2; LY2157299; LY 2157299; LY-2157299; 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; TGF-β-Smad inhibitor

MDL: MFCD12923319
CAS Number: 700874-72-2
Compound CID: 10090485

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY2157299, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets TβRI.

Molecular Weight

369.4

Molecular Formula

C₂₂H₁₉N₅O

Targets

TβRI: 56 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 66 mg/mL (178.65 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

LY2157299 can be used to study its inhibition of TGF-β receptor I kinase and its potential therapeutic applications in fibrosis and cancer.