TGF-β-Smad inhibitor RepSox, Purity ≥98%

Synonym: RepSox; 446859-33-2; 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; ALK5 Inhibitor II; ALK5 Inhibitor; TGF-β-Smad inhibitor

MDL: MFCD09037561
CAS Number: 446859-33-2
Compound CID: 449054

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RepSox, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets TGFβR1 (ALK5).

Molecular Weight

287.32

Molecular Formula

C₁₇H₁₃N₅

Targets

TGFβR1 (ALK5): 4 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 49 mg/mL (170.54 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

RepSox can be used to study the inhibition of TGF-β type I receptor (ALK5) in processes such as cellular differentiation and fibrosis.

Storage

Store at -20ºC.