TGF-β-Smad inhibitor SB 431542, Purity ≥98%

Synonym: 301836-41-9; SB-431542; SB 431542; 4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; SB431542; 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE; TGF-β-Smad inhibitor

MDL: MFCD05865244
CAS Number: 301836-41-9
Compound CID: 4521392

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 431542, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK4, ALK5, and ALK7.

Molecular Weight

384.4

Molecular Formula

C₂₂H₁₆N₄O₃

Targets

ALK4; ALK5: 94 nM; ALK7

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 75 mg/mL (195.11 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.8 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

SB 431542 can be used to study its inhibition of TGF-β1 receptor kinase and its effects on cellular processes such as proliferation and differentiation.