Properties
Description
SB 431542, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK4, ALK5, and ALK7.
Molecular Formula
C22H16N4O3
Targets
ALK4; ALK5: 94 nM; ALK7
Solubility
DMSO: 75 mg/mL (195.11 mM); Water: Insoluble; Ethanol: 3 mg/mL (7.8 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
SB 431542 can be used to study its inhibition of TGF-β1 receptor kinase and its effects on cellular processes such as proliferation and differentiation.