Properties
Description
SB-505124, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK4 and ALK5.
Molecular Formula
C20H21N3O2
Targets
ALK4: 129 nM; ALK5: 47 nM
Solubility
DMSO: 65 mg/mL (193.8 mM); Water: Insoluble; Ethanol: 65 mg/mL (193.8 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
SB-505124 can be used to investigate its selective inhibition of TGF-β receptor I kinase and its effects on cellular responses to TGF-β signaling.