TGF-β-Smad inhibitor SB-505124, Purity ≥98%

Synonym: 694433-59-5; SB-505124; SB505124; 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine; SB 505124; TGF-beta RI Inhibitor III; 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl)-6-methylpyridine; TGF-β-Smad inhibitor

MDL: MFCD20926329
CAS Number: 694433-59-5
Compound CID: 9858940

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB-505124, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of TGF-β-Smad signaling pathway activation. It targets ALK4 and ALK5.

Molecular Weight

335.4

Molecular Formula

C₂₀H₂₁N₃O₂

Targets

ALK4: 129 nM; ALK5: 47 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 65 mg/mL (193.8 mM); Water: Insoluble; Ethanol: 65 mg/mL (193.8 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

SB-505124 can be used to investigate its selective inhibition of TGF-β receptor I kinase and its effects on cellular responses to TGF-β signaling.