Rapid weight loss is a common symptom in cancer patients. Weight loss and changes in body composition are all manifestations of cancer cachexia. Studies have shown that the accumulation of visceral fat and cytokines secreted by adipocytes promote the glucose metabolic abnormalities associated with cancer cachexia. Excess adipose tissue can produce inflammatory cytokines, leading to the formation of a tumor microenvironment that promotes cancer progression. Data such as subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle mass can be monitored using magnetic resonance imaging and computed tomography. These data have been shown to be related to cachexia in cancer patients. Therefore, studying the relationship between body weight composition and changes in cancer glucose metabolism can bring new ideas for cancer diagnosis and therapy. CD BioGlyco provides mice body mass composition test services.

Fig. 1 Different types of body composition models (Kuriyan R, et al., 2018)

What We Do

• We are able to measure the weight, fat mass, and fat mass percentage of the mice before and after the glucose metabolism intervention.
• We are able to measure the lean mass, free water, and total water of the mice before and after the glucose metabolism intervention.
• We are able to measure the energy expenditure and food intake of the mice before and after the glucose metabolism intervention.

Our Workflow

After the intervention of the glucose metabolism pathway according to the experimental purpose, the body composition of each group of mice was assessed by magnetic resonance imaging technology. According to the customers’ request, the body composition of the mice is detected every other day, and the change curve of the body composition of the mice is drawn after the experiment.

Our Advantages

• Non-invasive testing.
• High repeatability.
• The required detection time is short, and it is suitable for the detection of a large number of samples.
• Suitable for the detection of different body positions.

Applications

• To investigate the relationship between altered glucose metabolism in cancer, body weight composition, and cancer progression.
• To explore the effect of cancer glucose metabolism regulation on the composition of tumor tissue.
• To explore the possibility of body mass composition as a criterion for cancer diagnosis and treatment effect assessment.

CD BioGlyco provides mice body mass composition test services. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.

Reference:

1. Kuriyan R. Body composition techniques. Indian J Med Res. 2018 Nov; 148(5): 648-658.