TNF-α inhibitor EVP4593, Purity ≥98%

Synonym: 545380-34-5; QNZ; EVP4593; QNZ (EVP4593); 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline; N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine; 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine; TNF-α inhibitor

MDL: MFCD06411436
CAS Number: 545380-34-5
Compound CID: 509554

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

EVP4593, soluble in warmed DMSO and insoluble in water and ethanol, is a compound that reduces inflammation by modulating apoptosis. It targets TNF-α (Jurkat T cells) and NF-κB (Jurkat T cells).

Molecular Weight

356.4

Targets

TNF-α (Jurkat T cells): 7 nM; NF-κB (Jurkat T cells): 11 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 5 mg/mL (14.02 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

EVP4593 can be explored for its role as an inhibitor of neuroprotective pathways and potential therapeutic application in neurodegenerative diseases.