TNF-α inhibitor EVP4593, Purity ≥98%

Synonym: 545380-34-5; QNZ; EVP4593; QNZ (EVP4593); 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline; N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine; 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine; TNF-α inhibitor

MDL: MFCD06411436
CAS Number: 545380-34-5
Compound CID: 509554

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

EVP4593, soluble in warmed DMSO and insoluble in water and ethanol, is a compound that reduces inflammation by modulating apoptosis. It targets TNF-α (Jurkat T cells) and NF-κB (Jurkat T cells).

Molecular Weight

356.4

Targets

TNF-α (Jurkat T cells): 7 nM; NF-κB (Jurkat T cells): 11 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 5 mg/mL (14.02 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

EVP4593 can be explored for its role as an inhibitor of neuroprotective pathways and potential therapeutic application in neurodegenerative diseases.

Storage

Store at -20ºC.