TNF-α inhibitor Necrostatin-1, Purity ≥98%

Synonym: 4311-88-0; Necrostatin-1; MTH-DL-tryptophan; Necrostatin 1; Nec-1; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone; 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one; TNF-α inhibitor

MDL: MFCD00056916
CAS Number: 4311-88-0
Compound CID: 2828334

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Necrostatin-1, soluble in warmed DMSO and insoluble in water and ethanol, is a compound that reduces inflammation by modulating apoptosis. It targets RIP1 (293T cells).

Molecular Weight

259.33

Molecular Formula

C₁₃H₁₃N₃OS

Targets

RIP1 (293T cells): 490 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 43 mg/mL (165.81 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Necrostatin-1 is used to study the inhibition of necroptosis, a form of programmed cell death, and its potential therapeutic implications.