Properties
Description
Idarubicin HCl, soluble in DMSO and warmed water and insoluble in ethanol, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting topoisomerase. It targets the multicellular spheroids (cell-free assay) and Topo II (MCF-7 cells) (cell-free assay).
Molecular Formula
C26H28ClNO9
Targets
Multicellular spheroids (Cell-free assay): 7.9 ng/mL; Topo II (MCF-7 cells) (Cell-free assay): 3.3 ng/mL
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 88 mg/mL (164.81 mM); Water (warmed): 4 mg/mL (7.49 mM); Ethanol: insoluble
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
Idarubicin HCl is a DNA damage inhibitor that plays a key role in inhibiting topoisomerase II and inducing oxidative stress, which leads to cell death.
Storage
Store at -20ºC, and keep desiccated.
