Trk receptor inhibitor GNF 5837, Purity ≥98%

Synonym: 1033769-28-6; Trk receptor inhibitor; GNF-5837; GNF5837

MDL: MFCD24386809
CAS Number: 1033769-28-6
Compound CID: 59397065

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GNF 5837, soluble in DMSO and warmed ethanol and insoluble in water, blocks the activity of tropomyosin receptor kinases, which are involved in the growth and survival of neurons. It targets TrkA, TrkB, Abl, ALK, CSF-1R, FGFR3, FGFR4, FLT3, IGF-1R, Insulin receptor, and JAK2.

Molecular Weight

535.49

Molecular Formula

C₂₈H₂₁F₄N₅O₂

Targets

TrkA: 11 nM; TrkB: 9 nM; Abl: 8.2 nM; ALK: 3.4 nM; CSF-1R: 4 μM; FGFR3: 9.3 μM; FGFR4: 7 μM; FLT3: 5.1 μM; IGF-1R: 7.6 μM; Insulin receptor: 8 μM; JAK2: 2.9 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (171.8 mM); Water: Insoluble; Warmed ethanol: 8 mg/mL (14.93 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

GNF 5837 is examined for its role in inhibiting Trk kinases, relevant in researching treatments for cancers and neurological disorders.