Trk receptor inhibitor GW 441756, Purity ≥98%

Synonym: 504433-23-2; Trk receptor inhibitor; GW-441756; GW441756

CAS Number: 504433-23-2
Compound CID: 9943465

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GW 441756, soluble in DMSO and insoluble in ethanol and water, blocks the activity of tropomyosin receptor kinases, which are involved in the growth and survival of neurons. It targets C-Raf-1, CDK2, and TrkA.

Molecular Weight

275.31

Molecular Formula

C₁₇H₁₃N₃O

Targets

C-Raf-1: >12 μM; CDK2: >7 μM; TrkA: 2 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 25 mg/mL (90.81 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GW 441756 is used to block Trk receptor activity, which can aid in the research of therapies for pain and neurodegenerative diseases.