Trk receptor inhibitor MGCD516, Purity ≥98%

Synonym: 1123837-84-2; Trk receptor inhibitor; MGCD516; MG516

CAS Number: 1123837-84-2
Compound CID: 25212148

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MGCD516, soluble in DMSO and ethanol and insoluble in water, blocks the activity of tropomyosin receptor kinases, which are involved in the growth and survival of neurons. It targets Axl, DDR1, DDR2, FLT3, KIT, Mer, TrkA, TrkB, VEGFR1, VEGFR2, and VEGFR3.

Molecular Weight

629.68

Molecular Formula

C₃₃H₂₉F₂N₅O₄S

Targets

Axl: 1.5 nM; DDR1: 29 nM; DDR2: 0.5 nM; FLT3: 8 nM; KIT: 6 nM; Mer: 2 nM; TrkA: 5 nM; TrkB: 9 nM; VEGFR1: 6 nM; VEGFR2: 5 nM; VEGFR3: 2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 98 mg/mL (155.63 mM); Water: Insoluble; Ethanol: 98 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

MGCD516 is employed in the study of multiple kinase pathways including MET, VEGFR, and TRK, relevant for cancer therapy research.