Trk receptor inhibitor Selitrectinib, Purity ≥98%

Synonym: 2097002-61-2; Trk receptor inhibitor; LOXO-195; LOXO 195; LOXO 195

CAS Number: 2097002-61-2
Compound CID: 129103609

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Selitrectinib, soluble in DMSO and ethanol and insoluble in water, blocks the activity of tropomyosin receptor kinases, which are involved in the growth and survival of neurons. It targets TrkA and TrkB.

Molecular Weight

380.42

Molecular Formula

C₂₀H₂₁FN₆O

Targets

TrkA: 0.6 nM; TrkB: <2.5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 35 mg/mL (91.99 mM); Water: Insoluble; Ethanol: 14 mg/mL (36.8 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Selitrectinib is used to research its precision inhibition of TRK fusion proteins in cancer, supporting targeted oncological therapy studies.