Role of MSGb5Cer Antigen

Tumor cells overexpress some specific glycan structures on their surface, which are called "tumor-associated glycan antigens". These tumor-associated glycan antigens are important molecular markers on the surface of tumor cells, so it is important to obtain structurally homogeneous and defined glycan antigens for studying their biological activities and developing anti-tumor vaccines. Among such antigens, MSGb5Cer antigen is a specific antigen against tumor cells and is highly expressed in many types of tumor cells. Currently, based on its ability to be overexpressed on the surface of a wide range of tumor cells, the MSGb5Cer antigen has become a target for novel tumors and can be used to synthesize vaccine candidates for the prevention of tumors and to induce the formation of antibodies against and cancer cells.

Tumor-Associated MSGb5Cer Antigen Production Service at CD BioGlyco

CD BioGlyco has a specialized Vaccine Development Platform and provides a range of vaccine development services. Among them, in the development of tumor-related vaccines, we have mastered the production method of MSGb5Cer antigen.

• Chemical-enzymatic method
  • The chemoenzymatic method we provide combines the features of chemical and enzymatic methods to synthesize MSGb5Cer antigen more efficiently.
  • First, we synthesize the core sugar structure after chemical manipulation, followed by fucosylation modification using glycosyltransferase, and finally complete the synthesis of MSGb5Cer antigen.
  • Advantages: stereoselective and regioselective, high efficiency.
• Chemical method
  • We synthesize MSGb5Cer antigen by using simple glycosides as starting materials, through protection-deprotection operation and isolation and purification operation.
  • Advantages: good flexibility, and wide-ranging.

We take advantage of the fact that MSGb5Cer antigen is overexpressed on the surface of a wide range of tumor cells and use it in combination with other essential substances such as stabilizers to synthesize tumor-associated vaccine candidates that induce the formation of antibodies against tumor cells as well as cancer cells.

Fig.1 Methods of producing MSGb5Cer antigen. (CD BioGlyco)

Applications

• MSGb5Cer antigen can be used in the development of tumor-related vaccines.
• The structure of MSGb5Cer antigen belongs to carbohydrates, so it can be used to study the physiological functions of carbohydrates.
• MSGb5Cer antigen is highly expressed in tumor cells and cancer cells, so it can be used in oncology and cancer therapy research.

Advantages

• We have a variety of MSGb5Cer antigen production routes to choose from.
• We have established a systematic vaccine development platform to support antigen production.

CD BioGlyco has established a vaccine development platform and has conducted comprehensive research and Development of Carbohydrate Vaccines. Among them, in the development of tumor-related vaccines, we also provide related antigen production services to our customers. If you are interested in our services, please feel free to contact us for more details.

Reference

1. Sato, B.; et al. Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in the development of mouse preimplantation embryos at the cleavage stage. BMC Developmental Biology. 2011, 11: 22.